ContactCRYOTOP®
Achieve the highest survival rates on the market with the Cryotop® Method, the global leader in vitrification of oocytes and embryos in all stages of development.
The revolutionary device by Kitazato has been applied in over 1,500,000 clinical cases for oocytes and embryos with this method of cryopreservation during the last decade, obtaining excellent results in over 90 countries and 2,200 assisted reproduction centres. The Cryotop® method is simple, safe, universal and easy to apply for everyone.
Cryotop® is a vitrification device consisting of a fine strip of transparent film attached to a plastic handle resistent to liquid nitrogen. Its design allows the loading of specimens for vitrification with a minimum volume (0.1 µl), providing the best Cooling and Warming rates on the market (-23,000ºC/minute and 42,000ºC/minute respectively) which in turn lead to the best survival rates.
Highest survival rates
Cryotop® Method offers proof of its outstanding results. Our suvival rates over 90% are backed up by numerous clinical studies with the biggest sample sizes in the market.
- 100%
- 90%
- 80%
- 70%
- 60%
- 50%
- 40%
- 30%
- 20%
- 10%
- 0%
- Oocytesn=3.286
Cobo
2010 - Oocytesn=124
Rienzi
2010 - Oocytesn=168
Parmegiani
2011 - Oocytesn=898
Solé
2013 - Embryosn=124
Rienzi
2012 - Embryosn=168
Parmegiani
2012 - Embryosn=898
Solé
2013 - Blastocystsn=168
Parmegiani
2011 - Blastocystsn=898
Solé
2012
Cryotop® Survival rates in human specimen
Main characteristics:
- Allows up to 4 specimens to be loaded per device.
- It has an external covering to protect the Cryotop® once vitrified. Tip with weight to prevent floating in liquid nitrogen.
- Manufactured in malleable plastic resistant to liquid nitrogen.
- Available in packs of 10 units.
Cryotop® is the logical choice for obtaining the best clinical results. Its unparalleled survival rates for oocytes and embryos have contributed to bringing hundreds of healthy babies into the world in the last decade.
Accessories
Repro plate
Exclusively designed to follow the vitrification protocol with comfort; offers two slots to support the Cryotop®, allowing those who wish to carry out loading specimens statically. Has a flat base which allows the use of traceability labels.
Cooling rack
Designed to contain the liquid nitrogen during vitrification. Metallic cover for the interior also available, allowing sterilisation before use.
- Endotoxin: ≤ 0.5EU/device by LAL methodology
- Sterility (Bacteria, Fungi): current USP Sterility Test <71>
- MEA (Mouse Embryo Assay): One cell assay ≥ 80% after 96 hours
Instructions
- Cobo A., Outcome of cryotransfer of embryos developed from vitrified oocytes: double vitrification has no impact on delivery rates. Fertility & Sterility, 2013.
- Chang C., Prospective controlled study to evaluate laboratory and clinical outcomes of oocyte vitrification obtained in vitro fertilization patients aged 30 to 39 years. Fertitliy &Sterility, 2013.
- Shi W., Perinatal and neonatal outcomes of 494 babies delivered from 972 vitrified embryo transfers. Fertility &Sterility, 2012.
- Cobo A., Outcomes of vitrified early cleavage-stage and bastocyst-stage embryos in a cryopreservation program: evaluation of 3,150 warming cycles. Fertility & Sterility, 2012.
- Kato O., Neonatal outcome and birth defects in 6623 singletons born following minimal ovarian stimulation and vitrified versus fresh single embryo transfer. European Journal Obstetricts & Gynecol and Reproductive, 2011.
- Zhu D., Vitrified-warmed blastocyst transfer cycles yield higher pregnancy and implantation rates compared with fresh blastocyst transfer cycles—time for a new embryo transfer strategy? Fertility & Sterility, 2011.
- Trokudes KM., Comparison outcome of fresh and vitrified donor oocytes in an egg-sharing donation program. Fertility & Sterility Vol.95 1996-2000, 2011.
- Lin TK., Cryotop vitrification as compared to conventional slow freezing for human embryos at the cleavage stage: survival and outcomes. Taiwan J Obstet Gynecol, 2010.
- Inoue F., Hidroxypropyl Cellulose as a macromolecular supplement for cryopreservation by vitrification of bovine oocytes and blastocysts and human oocytes. ESRHE and ASRM 2011.
- Cobo A., Use of cryo-banked oocytes in an ovum donation program: a prospective, randomized, controlled, clinical trial. Human Reproduction, 2010.
- Rienzi L., Embryo development of fresh “versus” vitrified metaphase II oocyte after ICSI: a prospective randomized sibling-oocyte study. Human Reproduction Vol.0 1-8, 2009.
- Nagy P., Clinical evaluation of the efficiency of an oocyte donation program using egg cryo-banking. Fertility & Sterility Vol.92-2 520-526, 2009.
- Inoue F., High post-warm survival of bovine oocytes vitrified with serum-free medium containing hydroxypropyl cellulose. Low Temp. Med. 2009.
- Cobo A., Vitrification: an effective new approach to oocyte banking and preserving fertility in cancer patients. Clin Trans Oncolo, 2008.
- Chang C., Human oocyte vitrification: in-vivo and in-vitro maduration outcomes. Reproductive BioMedicine Online 17:684-688, 2008.
- Cobo A., Comparison of concomitant outcome achieved with fresh and cryopreserved donor oocytes vitrified by the Cryotop method. Fertility & Sterility, 2008.
| ORDER NUMBER | CODE | DESCRIPTION |
| 81115 | CR-Y | Cryotop® Yellow |
| 81114 | CR-B | Cryotop® Blue |
| 81113 | CR-W | Cryotop® White |
| 81112 | CR-R | Cryotop® Red |
| 81111 | CR-G | Cryotop® Green |
| K | Reproplate | |
| 94123 | SET RACK-L | Cooling Rack+Steel Box-Large |
| 94122 | SET RACK-S | Cooling Rack+Steel Box-Short |
| 91101 | VT601 | Vitrification Solutions * |
| 91121 | VT602 | Thawing Solutions * |
| 91171 | VT801 | Vitrification Solutions |
| 91182 | VT802 | Thawing Solutions |
| 81125 | CR SC-Y | Cryotop® SC Yellow |
| 81124 | CR SC-B | Cryotop® SC Blue |
| 81123 | CR SC-W | Cryotop® SC White |
| 81122 | CR SC-R | Cryotop® SC Red |
| 81121 | CR SC-G | Cryotop® SC Green |
| 84115 | BLOCK SC | Aluminum Block for Cryotop® SC |
| 84117 | CUTTER SC | Straw Cutter for Cryotop® SC |
| 84119 | HEAT SEALER | Heat Sealer for Cryotop® SC |
